Lactulose, known as "the bifidobacterium growth factor", is a disaccharide composed of galactose and fructose linked together with β-(1,4) glycosidic bond. It has unique physiological functions and is widely used in food, medicine, health care products and other fields.
Lactulose, known as "the bifidobacterium growth factor", is a disaccharide composed of galactose and fructose linked together with β-(1,4) glycosidic bond. It has unique physiological functions and is widely used in food, medicine, health care products and other fields.
Product Property
Lactulose liquid is light yellow, clear and sticky, and tastes sweet. Lactulose also comes in the form of white crystalline powder that is soluble in water. The relative density of lactulose powder is 1.35, and the melting point is 169℃. Its sweetness is 48% to 70% of sucrose, with a cool and refreshing flavor. With low viscosity, low calorie, high safety, good stability, it will not cause Maillard reaction. Lactulose is stable under acidic conditions and is not easily absorbed by the human body. It works mainly in the gut.
Product Application
1. Food
• Sweetener: Lactulose can be used as a low-calorie sweetener for beverages, candies, dairy products, etc.
• Functional foods: Lactulose can regulate intestinal flora and is often added to functional foods, such as prebiotic drinks and prebiotic biscuits.
2. Health care products and other fields
• Prebiotics: Lactulose can improve intestinal health, strengthen immunity, and is often used in health care products.
• Foods for Special Dietary: Lactulose is used in diabetic foods and infant formula to maintain blood sugar and insulin levels.
3. Medicine
• Treatment for constipation: Lactulose is commonly used to treat chronic constipation and is suitable for adults, children and the elderly.
• Treatment for hepatic encephalopathy: Lactulose can effectively reduce blood ammonia levels, so it is usually the first choice for treatment of hepatic encephalopathy.
• Others: Lactulose can also be used to treat acute coronary syndrome, chronic renal failure, acute pancreatitis and other diseases.
Usage and dosage of pharmaceutical grade lactulose
1. Treatment for constipation
• Adults: 30mL/day. Maintenance dose: 10-25mL.
• Children aged 7 to 14years: 15 mL/day
Children aged 1 to 6 years: 10 mL/day
Babies: 5 mL/day.
2. Treatment for hepatic encephalopathy
• Adults: Loading dose 30-50mL, three times a day. The maintenance dose should be adjusted according to the condition.
• Please seek advice from your doctor or pharmacist when using lactulose.
Executive standard
Lactulose Liquid
GB1886.176—2016
| Item | Index | ||
| Solid | Liquid | ||
| Sensory Index | Colour | White to Off-White | Colorless to Deep Yellow |
| Form | Crystalline Powder | Transparent Liquid | |
| Physical & Chemical Index | Lactulose Content w/%≥ | 97 | 50 |
| Fructose Content w/%≤ | 1.0 | ||
| Galactose Content w/%≤ | 11.0 | ||
| Epilactose Content w/%≤ | 4.0 | ||
| Lactose Content w/%≤ | 6.0 | ||
| Ph | 3-7 | ||
| Residue On Ignition w/% | 0.5 | ||
| Lead（Pb）/Mg/Kg | 1.0 | ||
| Arsenic（As）/Mg/Kg | 1.0 | ||
| Microorganism | Total Bacterial Count /（Cfu/g）≤ | 1000 | |
| Escherichia Coli /（Mpn/g）≤ | 3.0 | ||
| Salmonella /（25g） | Not Detected | ||
Lactulose
EP10.0
| Item | Index | |
| Sensory Index | Appearance | White To Off-White |
| Form | Crystalline Powder | |
| Physical & Chemical Index | Lactulose Content w/% | 95.0％ — 102.0％ |
| Epilactose Content w/%≤ | 0.9 | |
| Lactose Content w/%≤ | 1.2 | |
Melting Poin ℃ | 168 | |
| Specific Rotation | -50.0 — -46.0 | |
| Ph | 3-7 | |
| Residue On Ignition w/%≤ | 0.1 | |
| Boron（b）/Mg/Kg≤ | 9 | |
| Microorganism | Total Bacterial Count /（Cfu/g）≤ | 102 |
| Escherichia Coli /（Mpn/g）≤ | Not Detected | |
Lactulose Concentrated Solution
Chinese Pharmacopoeia
| Item | Index | |
| Sensory Index | Appearance | Colorless To Brownish Yellow Viscous Liquid |
| Physical & Chemical Index | Lactulose Content g/Ml | 63.0％—73.0％ |
| Fructose Content w/%≤ | 0.63 | |
| Galactose Content w/%≤ | 9.45 | |
| Epilactose Content w/%≤ | 6.3 | |
| Lactose Content w/%≤ | 6.3 | |
| Tagatose w/%≤ | 2.52 | |
| Relative Density | 1.260 —1.390 | |
| Color Of Solution(Ultraviolet Visible Spectrophotometry, General Rule 0401) | The Absorbance Measured At 420nm Shall Not Exceed 0.5 | |
| Ph | 3-7 | |
| Residue On Ignition w/%≤ | 0.1 | |
| Lead（Pb）/Mg/Kg≤ | 20 | |
