Shijiazhuang Huaxu Pharmaceutical Co.,Ltd
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Mannitol
Mannitol is a hexanol with a sweet taste. Because of the absorption of heat during the dissolution, it has a comfortable feeling to the mouth, so it is widely used in the manufacture of chewable tablets such as antialcoholic medicine and mouth cooling agent. Mannitol granules are used as excipients for direct compression in tablets and Mannitol can be used as base materials for nitroglycerin tablets.
Mannitol Application
Mannitol is used as raw materials for large volume parenterals, to produce Mannitol Injection, which has the efficacy of reducing intracranial pressure, intraocular pressure and diuresis. As filler and excipient, Mannitol is used in tablets for Anticancer medicine, Antibacterial medicine, Antihistamines medicine, Vitamins, Antialcoholic medicine, Refreshing agent. As cerebral vasodilator, Mannitol is for the treatment of cerebral vascular infarction, As diuretics, Mannitol is a mild laxative, it has special effects on oliguria and renal function deline caused by edema and burns.
Mannitol is one of the main products of Shijazhuang Huaxu Pharmaceutical CO., LTD.with good price and quality, factory direct sales. Our company is a professional supplier and from China manufacturer, with various products on sale and Cheap.
Mannitol Standard | ||||
ITEM | CP2015 | BP2018 | EP9.2 | USP41 |
Appearance |
white crystals or crystalline power,odorless | |||
Solubility | Freely soluble in water,very slightly soluble in ethanol | |||
Identification:Melting point | 166~170℃ | 165~170℃ | 165~170℃ | |
Specific optical rotation | +137°~+145° | +23°~+25° | +23°~+25° | |
Identification:FeCl3 | Positive | —— | —— | |
Identification:Infrared absorption spectrophotometry | Conformity | |||
Identification:TLC | —— | Conformity | Conformity | |
Acidity | Conformity | —— | —— | |
Appearance of solution | Clear and colourless | |||
Related substance | ≤2.0% | Conformity | Conformity | |
Reducing sugars |
≥12.8ml |
≤0.1% | ≤0.1% | |
Chloride | ≤0.003% | —— | ||
Sulphate | ≤0.01% | —— | ||
Oxalate | ≤0.02% | —— | ||
Loss on drying | ≤0.5% | ≤0.5% | ≤0.5% | |
Residue on lgnition | ≤0.1% | —— | ||
Heavy metals |
≤10ppm |
—— | —— | |
Arsenic | ≤2ppm | —— | —— | |
Conductivity | —— | ≤20us/cm | ≤20us/cm | |
Nickel | —— | ≤1ppm | <1ug/g | |
Assay | 98.0~102.0% | 97.0~102.0% | 97.0~102.0% | |
Bacterial endotoxins | —— | <2.5cuf/g | <2.5cuf/g | |
The total viable aerobic count | —— | ≤100us/cm | ≤100us/cm | |
Molds and yeasts | —— | ≤100us/cm | ≤100us/cm | |
Escherichia coli | —— | Negative/g | Negative/g | |
Salmonella | —— | Negative/10g | Negative/10g |