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Shijiazhuang Huaxu Pharmaceutical Co.,Ltd 

Tel: 0086-311-89105105  0086-311-89105106  0086-311-89105107  0086-311-89105108  0086-311-89105199

E-mail:Susan Wang:lerryer@hotmail.com        Anna Zhao:pharmachina@hotmail.com 

              Steven Lu:lujun-lujun@hotmail.com        Jesse Ji:Jessehuaxu@hotmail.com

              Ashley Li :ashleyhuaxu@hotmail.com
Fax:0086-311-89105200

Add: No.33 industrial street,Econimic development zone,Shijiazhuang city,Hebei,China

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Mannitol

Mannitol is a hexanol with a sweet taste. Because of the absorption of heat during the dissolution, it has a comfortable feeling to the mouth, so it is widely used in the manufacture of chewable tablets such as antialcoholic medicine and mouth cooling agent. Mannitol granules are used as excipients for direct compression in tablets and Mannitol can be used as base materials for nitroglycerin tablets.
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Huaxu Pharmaceutical

Mannitol is a hexanol with a sweet taste. Because of the absorption of heat during the dissolution, it has a comfortable feeling to the mouth, so it is widely used in the manufacture of chewable tablets such as antialcoholic medicine and mouth cooling agent. Mannitol granules are used as excipients for direct compression in tablets and Mannitol can be used as base materials for nitroglycerin tablets.

Application

Mannitol is used as raw materials for large volume parenterals, to produce Mannitol Injection, which has the efficacy of reducing intracranial pressure, intraocular pressure and diuresis. As filler and excipient, Mannitol is used in tablets for Anticancer medicine, Antibacterial medicine, Antihistamines medicine, Vitamins, Antialcoholic medicine, Refreshing agent. As cerebral vasodilator, Mannitol is for the treatment of cerebral vascular infarction, As diuretics, Mannitol is a mild laxative, it has special effects on oliguria and renal function deline caused by edema and burns.

 

Mannitol Standard
ITEM CP2015 BP2018 EP9.2 USP41

Appearance

white crystals or crystalline power,odorless
Solubility Freely soluble in water,very slightly soluble in ethanol
Identification:Melting point 166~170℃ 165~170℃ 165~170℃
Specific optical rotation +137°~+145° +23°~+25° +23°~+25°
Identification:FeCl3 Positive —— ——
Identification:Infrared absorption spectrophotometry Conformity
Identification:TLC —— Conformity Conformity
Acidity Conformity —— ——
Appearance of solution Clear and colourless
Related substance ≤2.0% Conformity Conformity
Reducing sugars

≥12.8ml

≤0.1% ≤0.1%
Chloride ≤0.003% ——  
Sulphate ≤0.01% ——  
Oxalate ≤0.02% ——  
Loss on drying ≤0.5% ≤0.5% ≤0.5%
Residue on lgnition ≤0.1% ——  
Heavy metals

≤10ppm

—— ——
Arsenic ≤2ppm —— ——
Conductivity —— ≤20us/cm ≤20us/cm
Nickel —— ≤1ppm <1ug/g
Assay 98.0~102.0% 97.0~102.0% 97.0~102.0%
Bacterial endotoxins —— <2.5cuf/g <2.5cuf/g
The total viable aerobic count —— ≤100us/cm ≤100us/cm
Molds and yeasts —— ≤100us/cm ≤100us/cm
Escherichia coli —— Negative/g Negative/g
Salmonella —— Negative/10g Negative/10g

 

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